Bazzite
Bazzite is an immutable Linux distribution based on Fedora and designed with gaming in mind. It can run on desktop computers, the Steam Deck, and other handheld gaming devices.
VS
Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.