CachyOS
CachyOS is a Linux distribution based on Arch Linux. It focuses on speed and security optimisations - the default Linux kernel is heavily optimised using the BORE (Burst-Oriented Response Enhancer) scheduler, while the desktop packages are compiled with LTO, x86-64-v3 and x86-64-v4, Zen 4 optimization, security flags and performance improvements.
VS
Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.