Nitrux
Nitrux is a desktop Linux distribution built from Debian, but with an immutable base system, the OpenRC init system, and without any traditional Debian package management tools. It uses the Calamares system installer and includes the Hyprland window manager, Hypr utilities, the greetd+QtGreet login manager, and the Waybar Wayland bar.
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Vanilla OS
Vanilla OS, a fixed-release distribution based on Debian (formerly Ubuntu, prior to version 2) with the GNOME desktop, is an immutable operating system. The core parts of the system are locked down to prevent unwanted changes and corruption from third-party applications or a faulty update.