NixOS
NixOS is an independently developed GNU/Linux distribution that aims to improve the state of the art in system configuration management. In NixOS, the entire operating system, including the kernel, applications, system packages and configuration files, are built by the Nix package manager.
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Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.