Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.
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AerynOS
AerynOS is an independently-developed, rolling-release Linux distribution designed for general desktop use. Its main features include the GNOME desktop, a custom package manager called "moss", atomic updates with rollback options, a package build system called "boulder", and smart boot management with complex EFI configuration through a utility called "blsforme".