Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.
VS
Artix Linux
Artix Linux is a fork (or continuation as an autonomous project) of the Arch-OpenRC and Manjaro-OpenRC projects. Artix Linux offers a lightweight, rolling-release operating system featuring the OpenRC init software.