Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.
VS
blendOS
blendOS is an Arch Linux-based, rolling-release distribution which automates installing software from supported distributions (Arch Linux, Fedora and Ubuntu) into containers. blendOS tries to make software management in across containers feel native and provides access to the user's home directory for each container.