Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.
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Nitrux
Nitrux is a desktop Linux distribution built from Debian, but with an immutable base system, the OpenRC init system, and without any traditional Debian package management tools. It uses the Calamares system installer and includes the Hyprland window manager, Hypr utilities, the greetd+QtGreet login manager, and the Waybar Wayland bar.