Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.
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Solus
Solus is a Linux distribution built from scratch. It uses a forked version of the PiSi package manager, maintained as "eopkg" within Solus, and its flagship edition uses the Budgie desktop environment.