Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.
VS
Talos Linux
Talos is a specialist Linux-based operating system for running Kubernetes, an open-source system for automating deployment, scaling and management of containerised applications. Minimal, immutable and hardened, it does not offer any shell or interactive console; instead, all system management is done via remote Application Programming Interface (API) calls, where messages sent from a client application are protected with mutual Transport Layer Security TLS (mTLS) authentication.