Qubes OS
Qubes OS is a free and open-source, security-oriented operating system for single-user desktop computing. Qubes OS leverages Xen-based virtualization to allow for the creation and management of isolated compartments called qubes.
VS
Vendefoul Wolf
Vendefoul Wolf is a set of lightweight, Devuan-based Linux distributions featuring various popular desktop environments, including Budgie, Cinnamon, KDE Plasma, LXQt, Trinity and Xfce. As the init software, it offers a choice between SysV and runit.